Development of the quantitative PET prostate phantom (Q3P) for improved quality assurance of ¹⁸F‐PSMA PET imaging in metastatic prostate cancer

Background Phantoms are commonly used to evaluate and compare the performance of imaging systems given the known ground truth. Positron emission tomography (PET) scanners are routinely validated using the NEMA image quality phantom, in which lesions are modeled using 10 to 37 mm fillable spheres. The NEMA phantom neglects, however, to model focal (3–10‐mm), high‐uptake lesions that are increasingly observed in prostate‐specific membrane antigen (PSMA) PET images. PSMA‐targeting radiopharmaceuticals allow for enhanced detection of metastatic prostate cancers. As such, there is significant need to develop an updated phantom which considers both the quantitative and lesion detectability of this new paradigm in oncological PET imaging. Purpose In this work, we present the Quantitative PET Prostate Phantom (Q3P); a portable and modular phantom that can be used to improve and harmonize imaging protocols for 18 F‐PSMA PET scans. Methods A one‐piece cylindrical phantom was designed effectively in two halves, which we call modules. Module 1 was designed to mimic lesions in the presence of background, and Module 2 mimicked very high contrast conditions (i.e., very low background) that can be observed in 18 F‐PSMA PET scans. Shell‐less radioactive spheres (3–16‐mm) were cast using epoxy resin mixed with sodium‐22 ( 22 Na), a long half‐life positron emitter with positron range similar to 18 F. To establish realistic lesion contrast, the 22 Na spheres were mounted in a cylindrical chamber that can be filled with an 18 F background (module 1). Thirteen exchangeable spherical cavity inserts (3–37‐mm) were machined in two parts and solvent welded together, and filled with 18 F (50 kBq/mL) to model lesions with very high contrast (module 2). Five 2.5‐min PET scans were acquired on a 5‐ring GE Discovery MI PET/CT scanner (General Electric, USA). Lesions were segmented using 41% of SUV max fixed thresholding (41% FT) and recovery coefficients (RCs) were computed from 5 noise realizations. Results The manufactured phantom is portable (5.7 kg) and scan preparation takes less than 40 min. The total 22 Na activity is 250 kBq, allowing it to be shipped as an exempt package under International Atomic Energy Agency (IAEA) regulations. Recovery coefficients, computed using PSF modeling and no post‐reconstruction smoothing, were 130.3% (16 mm), 147.1% (10 mm), 87.2% (6 mm), and 7.0% (3 mm) for RC max , which decreased to 91.1% (16 mm), 90.6% (10 mm), 53.2% (6 mm), and 3.6% (3 mm) for RC mean in the 22 Na spheres. Comparatively, 18 F sphere recovery was 110.7% (17 mm), 123.6% (10 mm), 106.5% (7 mm), and 23.3% (3 mm) for RC max , which was reduced to 76.7% (17 mm), 77.7% (10 mm), 66.8% (7 mm), and 13.5% (3 mm), for RC mean . Conclusions A standardized imaging phantom was developed for lesion quantification assessment in 18 F‐PSMA PET images. The phantom is configurable, providing users with the opportunity to modify background activity levels or sphere sizes according to clinical demands. Distributed to the community, the Q3P phantom has the potential to enable better assessment of lesion quantification and harmonization of 18 F‐PSMA PET imaging, which may lead to more robust predictive metrics and better outcome prediction in metastatic prostate cancer.