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October 9, 2025Journal of Diabetes ResearchOpen Access

Gene Expression in Urinary Sediment Cells as an Indicator of the Contribution of Plasma Lipids to Diabetic Kidney Disease

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Authors

TZThainá Tavolaro ZocchioASAritânia Sousa SantosACAna Mercedes Cavaleiro

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Overview

Observational analysis reveals correlations between mRNA expression in urinary sediment cells and lipid profiles in type 1 diabetes, indicating metabolic involvement in diabetic kidney disease.

Key Points

  • Higher CD36 expression in urinary sediment cells relates to renal function decline in type 1 diabetes patients.
  • Notable correlations exist between CD36, IL1B, TGFB1, and urinary albumin excretion levels.
  • Plasma free fatty acid levels correlate positively with mRNA expression of CD36 and IL1B, linking lipids to kidney health.
  • The expression of lipid-related genes was modulated by statin and angiotensin II receptor blocker use, highlighting treatment impact.

Cite This Study

Zocchio et al. (2025) studied this question.

synapsesocial.com/papers/68e79cf2ed88661f66c2e2b8https://doi.org/10.1155/jdr/2349928
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