Observational analysis finds similar outcomes for surgical resection and surveillance in patients with ground-glass nodules, suggesting new management strategies.
HomeRadiologyVol. 317, No. 1 PreviousNext Reviews and CommentaryEditorialEqual Outcomes for Patients with Ground-Glass Nodules Managed with Surveillance versus Surgical ResectionMark M. Hammer1 Mark M. Hammer1 Author Affiliations1Department of Radiology, Mass General Brigham, 75 Francis St, Boston, MA 02115Address correspondence to: the author (email: [email protected]).Mark M. Hammer1 Published Online:Oct 7 2025https://doi.org/10.1148/radiol.252580See also the article by Liu and Li et al in this issue.MoreSectionsFull textPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In References1. Hattori A, Matsunaga T, Hayashi T, Takamochi K, Oh S, Suzuki K. Prognostic Impact of the Findings on Thin-Section Computed Tomography in Patients with Subcentimeter Non-Small Cell Lung Cancer. J Thorac Oncol 2017;12(6):954–962. Medline Google Scholar2. Sun JD, Sugarbaker E, Byrne SC, et al. Clinical Outcomes of Resected Pure Ground-Glass, Heterogeneous Ground-Glass, and Part-Solid Pulmonary Nodules. AJR Am J Roentgenol 2024;222(5):e2330504. Medline Google Scholar3. Obayashi K, Shimizu K, Nakazawa S, et al. The impact of histology and ground-glass opacity component on volume doubling time in primary lung cancer. J Thorac Dis 2018;10(9):5428–5434. Medline Google Scholar4. Kakinuma R, Noguchi M, Ashizawa K, et al. Natural History of Pulmonary Subsolid Nodules: A Prospective Multicenter Study. J Thorac Oncol 2016;11(7):1012–1028. Medline Google Scholar5. Lung‐RADS® v2022. American College of Radiology. https://edge.sitecorecloud.io/americancoldf5f-acrorgf92a-productioncb02-3650/media/ACR/Files/RADS/Lung-RADS/Lung-RADS-2022.pdf. Accessed November 9, 2023. Google Scholar6. Chen H, Kim AW, Hsin M, et al. The 2023 American Association for Thoracic Surgery (AATS) Expert Consensus Document: Management of subsolid lung nodules. J Thorac Cardiovasc Surg 2024;168(3):631–647.e11. Medline Google Scholar7. Li D, Deng C, Wang S, Li Y, Zhang Y, Chen H. Ten-Year Follow-up Results of Pure Ground-Glass Opacity–Featured Lung Adenocarcinomas After Surgery. Ann Thorac Surg 2023;116(2):230–237. Google Scholar8. Liu M, Li M, Zheng R, et al. Comparison of 10-year survival outcomes between CT surveillance and surgery for ground-glass nodules. Radiology 2025;317(1):e250366. Google Scholar9. MacMahon H, Naidich DP, Goo JM, et al. Guidelines for Management of Incidental Pulmonary Nodules Detected on CT Images: From the Fleischner Society 2017. Radiology 2017;284(1):228–243. Google Scholar10. Kim BG, Nam H, Hwang I, et al. The Growth of Screening-Detected Pure Ground-Glass Nodules Following 10 Years of Stability. Chest 2025;167(4):1232–1242. Medline Google ScholarArticle HistoryReceived: Aug 18 2025Revision requested: Sept 19 2025Revision received: Sept 19 2025Accepted: Sept 22 2025Published online: Oct 07 2025 FiguresReferencesRelatedDetailsAccompanying This ArticleComparison of 10-year Survival Outcomes between CT Surveillance and Surgery for Ground-Glass NodulesOct 7 2025Radiology Vol. 317, No. 1 Metrics Altmetric Score PDF download
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