Pillar[5]arene acts like an intelligent robot to efficiently regulate drug loading and release. Nanogold is widely used and shows advantages in oncology treatment; however, it cannot encapsulate drugs directly and effectively like other nanovesicles or nanocages. The modified pillar[5]arenecan endowed nanogold with excellent drug-loading ability through a simple host–guest interaction, and successfully achieved the combination of DOX and GOX for cancer therapy. More information can be found in the Research Article by L. Liu and co-workers (DOI: 10.1002/chem.202400007).
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Jiang et al. (2024) studied this question.
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