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October 9, 2025Immunological MedicineOpen Access

Clinical improvement of salt-and-pepper skin changes in juvenile systemic sclerosis using mycophenolate mofetil after intravenous methylprednisolone: a 3-year follow-up

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Authors

DHDaisuke HironakaYamaguchi UniversityHWHiroyuki WakiguchiYamaguchi UniversityFOFumiko OkazakiYamaguchi University

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Implication

Case report shows resolution of salt-and-pepper skin changes in juvenile systemic sclerosis using mycophenolate mofetil, indicating potential anti-fibrotic benefits.

Key Points

  • The modified Rodnan skin score improved from 25 to 0, demonstrating effective treatment in juvenile systemic sclerosis.
  • Intravenous methylprednisolone followed by mycophenolate mofetil demonstrated beneficial effects on skin changes in a 12-year-old patient.
  • This case is the first report documenting improvement of salt-and-pepper skin changes in juvenile systemic sclerosis after specific treatment.
  • Recognition of salt-and-pepper changes may prompt earlier diagnosis and intervention in juvenile systemic sclerosis cases.

Cite This Study

Hironaka et al. (2025) studied this question.

synapsesocial.com/papers/68e7d631bd66d359be62658chttps://doi.org/10.1080/25785826.2025.2570899
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mycophenolate mofetil in diffuse cutaneous systemic sclerosis--a retrospective analysis2006 · 205 citations
  2. 2Scleroderma (systemic sclerosis): classification, subsets and pathogenesis2001 · 3,972 citations
  3. 3Successful treatment of children with juvenile systemic sclerosis using mycophenolate mofetil after methylprednisolone pulse therapy: A 3‐year follow‐up2021 · 2 citations
  4. 4The Pediatric Rheumatology European Society/American College of Rheumatology/European League against Rheumatism provisional classification criteria for juvenile systemic sclerosis2007 · 221 citations