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February 12, 2026Dermatology ReportsOpen Access

Successful use of upadacitinib for the improvement of vitiligo-like and perifollicular dyspigmentation (salt-and-pepper skin) in systemic sclerosis

Dario Didona Matteo Riccardo Di Nicola Santo Raffaele Mercuri Paola Fiore

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Key Points

To evaluate the effectiveness of upadacitinib in improving skin conditions associated with systemic sclerosis.
Evaluated the impact of upadacitinib on vitiligo-like and perifollicular dyspigmentation.
Classified patients based on the extent of cutaneous involvement.
Documented clinical outcomes related to skin improvement.
Significant improvement in skin pigmentation was reported.
Patients exhibited reduced dyspigmentation and enhanced skin appearance.
Positive responses were observed across different subtypes of systemic sclerosis.

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Implication

Observational study shows improved skin pigmentation in systemic sclerosis patients, indicating potential therapeutic benefits.

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Cite This Study

Didona et al. (2026) studied this question.

synapsesocial.com/papers/6992b3769b75e639e9b082af https://doi.org/10.4081/dr.2026.10652

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Synapse has enriched 10 related papers. Consider them for comparative context:

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