Molybdenum Catalyzed Acceptorless Dehydrogenative Approach for Quinoline Synthesis Using Amino Alcohol

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This is a Experimental Study study.

Vaishnavi Atreya; A. K. SIL; Debangsu Sil; Subrata Chakraborty

doi:10.1039/d5ob01409c

January 1, 2025Organic & Biomolecular Chemistry

Molybdenum Catalyzed Acceptorless Dehydrogenative Approach for Quinoline Synthesis Using Amino Alcohol

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Key Points

The dehydrogenative annulation method forms quinoline from 2-aminobenzyl alcohol and methylketones.
Important findings include the successful creation of complex [Mo(CO)2(η3-C3H5)(DPPE)Cl] (Mo-1) facilitating the reaction.
Employing a molybdenum π-allyl complex highlighted new catalytic possibilities in organic synthesis.
This approach supports the potential for streamlined production of quinoline compounds.

Implication

This analysis reveals a dehydrogenative process forming quinoline in a variety of methylketones, suggesting novel reaction pathways.

Abstract

We report here bidentate phosphine-ligand based molybdenum π-allyl complex [Mo(CO)2(η3-C3H5)(DPPE)Cl] (Mo-1; DPPE ={1,2-bis(diphenylphosphino)ethane}) in the dehydrogenative annulation of 2-aminobenzyl alcohol with a wide variety of methylketones to form N-heterocycle quinoline...

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Cite This Study

Atreya et al. (2025) studied this question.

synapsesocial.com/papers/68e7d631bd66d359be626825 https://doi.org/10.1039/d5ob01409c

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Molybdenum Catalyzed Acceptorless Dehydrogenative Approach for Quinoline Synthesis Using Amino Alcohol

Key Points

Implication

Abstract

Discussion

Cite This Study

Molybdenum Catalyzed Acceptorless Dehydrogenative Approach for Quinoline Synthesis Using Amino Alcohol

Key Points

Implication

Abstract

Discussion

Cite This Study

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