A Hexadentate Co(III) Catalyst Enables One-Pot Quinazolinone Synthesis via Metal–Ligand Cooperative Alcohol Activation

Prashant Kukreti; Tanya Patnaik; Rahul Chauhan; Keshav Sharma; Rahul Saini; Kaushik Ghosh

doi:10.1039/d5ob01916h

January 1, 2025Organic & Biomolecular Chemistry

A Hexadentate Co(III) Catalyst Enables One-Pot Quinazolinone Synthesis via Metal–Ligand Cooperative Alcohol Activation

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Key Points

This research aims to demonstrate a new method for synthesizing quinazolinones using a Co(III) catalyst.
Developed a hexadentate Co(III) catalyst
Utilized acceptorless dehydrogenation of primary alcohols
Conducted reactions under air-stable conditions
Achieved efficient quinazolinone synthesis
Demonstrated metal-ligand cooperative activation
Showed potential for broader applications in organic synthesis

Implication

Research reveals a novel Co(III) catalytic method for synthesizing quinazolinone from alcohols, suggesting a new pathway for organic synthesis.

Abstract

Here, we present the first Co(III) catalysed efficient metal ligand cooperative route for the synthesis of quinazolinone using acceptorless dehydrogenation of primary alcohols. An air-stable phosphine-free Co(III) complex anchored by...

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Cite This Study

Kukreti et al. (2025) studied this question.

synapsesocial.com/papers/6971bd90642b1836717e23b5 https://doi.org/10.1039/d5ob01916h

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A Hexadentate Co(III) Catalyst Enables One-Pot Quinazolinone Synthesis via Metal–Ligand Cooperative Alcohol Activation

Key Points

Implication

Abstract

Discussion

Cite This Study

A Hexadentate Co(III) Catalyst Enables One-Pot Quinazolinone Synthesis via Metal–Ligand Cooperative Alcohol Activation

Key Points

Implication

Abstract

Discussion

Cite This Study

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