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October 9, 2025Journal of Biochemical and Molecular Toxicology

Taxifolin Attenuates Cisplatin‐Induced Acute Kidney Injury by Promoting Fatty Acid Oxidation

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Authors

XJXuejin JinHangzhou Medical CollegeLWLingkun WangChildren's Hospital of Zhejiang UniversityYMYuan MiaoDalian Medical University

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Implication

Observational analysis shows taxifolin reduces acute kidney injury in mice, indicating its role in lipid metabolism.

Key Points

  • Taxifolin significantly mitigated cisplatin-induced acute kidney injury in mice and human cells.
  • The treatment improved renal function and structural integrity, highlighting taxifolin's protective role.
  • Treatment involved modulating Fabp4-dependent fatty acid oxidation pathways to enhance lipid metabolism.
  • These findings suggest potential therapeutic strategies for cisplatin-associated nephrotoxicity.

Cite This Study

Jin et al. (2025) studied this question.

synapsesocial.com/papers/68e80eb363e2e2f707877bb4https://doi.org/10.1002/jbt.70559
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  4. 4Tubular cell senescence promotes maladaptive kidney repair and chronic kidney disease after cisplatin nephrotoxicity2023 · 127 citations