Key result
Fibroblast-specific NFκB deletion preserves LVEF and attenuates post-MI cardiac dysfunction and inflammation.
Why the study?
Does fibroblast-specific NFκB deletion prevent cardiac dysfunction and inflammation following myocardial infarction in mice?
Does fibroblast-specific NFκB deletion prevent cardiac dysfunction and inflammation following myocardial infarction in mice?
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Fibroblast-specific NFκB plays a critical role in fibroblast activation and inflammation, suggesting it as a potential therapeutic target for mitigating adverse cardiac remodeling post-MI.
Singh et al. (2025) studied Myocardial infarction. Fibroblast-specific NFκB deletion was evaluated on Cardiac dysfunction (ejection fraction and fractional shortening). Fibroblast-specific NFκB deletion restricted MI-induced cardiac dysfunction, restoring ejection fraction and reducing inflammation and fibroblast activation.
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