Key result
Extracellular fluid exposure triggers calcium-mediated swelling, rupture, and loss of respiratory function in viable mitochondria.
Population
Viable mitochondria isolated from the heart and skeletal muscle of healthy, adult C57BL/6J mice
Design
Preclinical
Follow-up
1 hour
Authors
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Isolated mitochondria become dysfunctional and lose respiratory capacity when exposed to extracellular spaces like plasma or ECF, challenging the mechanistic viability of mitochondrial transplantation for myocardial ischemia-reperfusion injury.
Isolated mitochondria become dysfunctional and lose respiratory capacity when exposed to extracellular spaces like plasma or ECF, challenging the mechanistic viability of mitochondrial transplantation for myocardial ischemia-reperfusion injury.
Abay et al. (2025) studied Ischemia-reperfusion injury. Exposure to plasma or myocardial extracellular fluid was evaluated on Mitochondrial swelling, rupture and loss of respiratory capacity. Exposure of isolated viable mitochondria to plasma or extracellular fluid for 1 hour resulted in Ca2+-induced swelling, rupture, and loss of respiratory capacity.
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