Key result
Mitochondrial transplantation improves myocardial function and reduces infarct size in DCD and ischemia-reperfusion injury models.
Why the study?
Mitochondrial transplantation has potential to improve outcomes in DCD heart transplantation by mitigating ischemia-reperfusion injury, but clinical validation is needed.
Does mitochondrial transplantation improve graft viability and function in DCD heart transplantation?
Population
DCD heart transplantation models primarily preclinical
Comparison
Mitochondrial transplantation with or without extracorporeal perfusion vs no mitochondrial transplantation
Design
Systematic review
Authors
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May enhance DCD graft viability with perfusion; extends preclinical data but clinical trials needed before adoption.
Systematic Review
Does mitochondrial transplantation improve graft viability and function in DCD heart transplantation?
Mitochondrial transplantation shows significant preclinical potential to mitigate ischemia-reperfusion injury and improve graft viability in DCD heart transplantation, especially when combined with ex vivo perfusion.
Zhang et al. (2025) conducted a systematic review in Donation after Circulatory Death (DCD) heart transplantation and ischemia-reperfusion injury. Mitochondrial transplantation vs. Standard preservation, vehicle, or untreated control was evaluated. Mitochondrial transplantation improves myocardial function, reduces infarct size, and modulates immune responses in DCD hearts and ischemia-reperfusion injury models.
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