What is the clinical evidence from this study?

Study design: Other. Population: Heart failure and cardiometabolic disease. Intervention: GRK2 overexpression vs. Control/sham. Primary outcome: White adipose tissue (WAT) depots and lipid accumulation.

What type of study is this?

This is a Cohort Study study (also classified as: Experimental Study).

October 9, 2025Circulation Research

Abstract Fri154: GRK2-mediated cardiomyocyte signaling factors are responsible for alterations in adiposity and mediate heart-fat communication

View Full Paper

Ask AI

Bookmark

Key result

Cardiac GRK2 overexpression accelerates white adipose tissue loss in male heart failure models.

Population

Adult rat cardiomyocytes, 3T3-L1 adipocytes, and mice with pressure overload-induced heart failure

Comparison

GRK2 overexpression vs Control conditioned media and sham mice

Design

Preclinical

Authors

SKStephanie M. KereliukDuke University MHMaya HoteitDuke University ABA. BochnerDuke University

Discussion

Member takes

Implication

Cardiomyocyte-secreted signaling factors, modulated by GRK2, influence adiposity in a sex-specific manner during heart failure.

Key Points

Cardiomyocyte secreted signaling factors influence adiposity, indicating a significant link between heart and fat.
GRK2 overexpression in cardiomyocytes reduced lipid accumulation in adipocytes and affected adipogenic markers.
Male mice with heart failure showed reduced white adipose tissue, while females exhibited no significant changes.
Findings suggest sex-specific differences in heart-to-fat communication and the role of GRK2 in adiposity.

Structured PICO

Population

Adult rat cardiomyocytes, 3T3-L1 adipocytes, and mice with pressure overload-induced heart failure

Intervention

GRK2 overexpression (in vitro in cardiomyocytes and in vivo in mice)

Comparator

Control conditioned media (in vitro) and sham mice (in vivo)

Outcome

Alterations in adiposity (lipid accumulation, adipogenic marker expression, and white adipose tissue depots)surrogate

Cardiomyocyte-secreted signaling factors, modulated by GRK2, influence adiposity in a sex-specific manner during heart failure.

Cite This Study

Kereliuk et al. (2025) studied Heart failure and cardiometabolic disease. GRK2 overexpression vs. Control/sham was evaluated on White adipose tissue (WAT) depots and lipid accumulation. Cardiac GRK2 overexpression exacerbated the reduction in white adipose tissue in male mice with pressure overload-induced heart failure, suggesting sex-specific heart-to-fat communication.

synapsesocial.com/papers/68e80eb363e2e2f707877d8f https://doi.org/10.1161/res.137.suppl_1.fri154

View Full Paper

Ask AI

Bookmark

Abstract Fri154: GRK2-mediated cardiomyocyte signaling factors are responsible for alterations in adiposity and mediate heart-fat communication

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Abstract Fri154: GRK2-mediated cardiomyocyte signaling factors are responsible for alterations in adiposity and mediate heart-fat communication

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider