Observational analysis reveals sex-specific cardiometabolic profiles in transgenic mice on high-fat diet, suggesting implications for metabolic health.
Key Points
Males on a high-fat diet showed better cardiac health and adipose function, while females experienced dysfunction and impaired signaling.
By 16 weeks, male mice had 3,701 ng/mL α-amino acid stereoisomer, while females had 6,042 ng/mL, indicating significant genotype-dependent differences.
Analysis involved serum metabolomics using HPLC-MS, assessing metabolite changes over time in high-fat diet mice compared with littermate controls.
Understanding these sex-specific changes may highlight novel therapeutic targets for obesity and associated metabolic disorders.