Key result
Estrogen depletion induces LV remodeling without provoking progressive arrhythmias in preclinical models.
Population
Young female ObscnΔIg58/59 mice and WT mice
Comparison
Surgical excision of ovaries and switch to… vs Sham bilateral surgery
Design
Preclinical
Authors
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In a mouse model of atrial cardiomyopathy, depletion of ovarian and dietary estrogens induced left ventricular remodeling but did not provoke progressive arrhythmias, suggesting other factors protect female hearts from dysfunction.
In a mouse model of atrial cardiomyopathy, depletion of ovarian and dietary estrogens induced left ventricular remodeling but did not provoke progressive arrhythmias, suggesting other factors protect female hearts from dysfunction.
Brong et al. (2025) studied Cardiac remodeling and arrhythmias. Ovariectomy and soy-free diet vs. Sham surgery was evaluated on Heart form and function via echocardiogram and electrocardiogram. Depletion of endogenous and exogenous estrogens induced age-specific remodeling of the left ventricle in ΔIg58/59 females but failed to provoke progressive arrhythmias.
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