Key result
Chronic estrogen protects cardiac function in ovariectomized females but worsens dysfunction in males.
Why the study?
Does chronic estrogen treatment have divergent sex-specific effects on cardiac function and ferroptosis in male versus ovariectomized female rats?
Population
Age-matched male and ovariectomized female (OVX) Sprague-Dawley rats
Comparison
Chronic estrogen (E2) for eight weeks vs Vehicle
Design
Preclinical
Follow-up
8 weeks
Authors
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Estrogen exhibits divergent sex-specific cardiac effects, protecting ovariectomized female rats while exacerbating cardiac dysfunction in males via Adora2b, Per2, and IL-6-mediated ferroptosis pathways.
Does chronic estrogen treatment have divergent sex-specific effects on cardiac function and ferroptosis in male versus ovariectomized female rats?
p-value: p=<0.05
Estrogen exhibits divergent sex-specific cardiac effects, protecting ovariectomized female rats while exacerbating cardiac dysfunction in males via Adora2b, Per2, and IL-6-mediated ferroptosis pathways.
Ahmed et al. (2025) studied Cardiovascular disease. Estrogen (E2) vs. Vehicle was evaluated on Blood pressure, cardiac function, and molecular markers (Adora2b, Per2, ferroptosis) (p=<0.05). Chronic estrogen treatment protected cardiac function in ovariectomized female rats but exacerbated cardiac dysfunction in male rats (p<0.05 for blood pressure and marker changes).
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