Key result
Estrogen depletion worsens methamphetamine-induced cardiomyopathy and mortality, while testosterone loss delays dysfunction in mice.
Why the study?
Does sex hormone depletion via gonadectomy alter the development of methamphetamine-induced dilated cardiomyopathy in mice?
Population
Murine model of methamphetamine-induced dilated cardiomyopathy
Comparison
Daily injections with an escalating dose of… vs Sham-operated meth-treated mice and opposite sex…
Design
Preclinical
Follow-up
5 months
Authors
Loading...
In a murine model, estrogen appears to protect against methamphetamine-induced cardiotoxicity, whereas testosterone may exacerbate the development of dilated cardiomyopathy.
Does sex hormone depletion via gonadectomy alter the development of methamphetamine-induced dilated cardiomyopathy in mice?
In a murine model, estrogen appears to protect against methamphetamine-induced cardiotoxicity, whereas testosterone may exacerbate the development of dilated cardiomyopathy.
Darrow et al. (2025) studied Methamphetamine-induced dilated cardiomyopathy. Methamphetamine and gonadectomy (ovariectomy or orchidectomy) vs. Methamphetamine and sham operation was evaluated on Cardiac function (ejection fraction, LV diameter) and survival. Ovariectomized female mice treated with methamphetamine had reduced ejection fraction and survival compared to sham females, while orchidectomy delayed the onset of cardiomyopathy in treated males.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: