Key result
Radiofrequency ablation creates a long-term sinus node dysfunction model in ~78% of swine.
Population
Nine Yucatan miniswine (31±3 kg)
Design
Preclinical
Follow-up
at least four months
Authors
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Radiofrequency ablation of the sinoatrial node successfully establishes a long-term miniature swine model of sinus node dysfunction, providing a valuable tool for researching arrhythmia mechanisms and alternative treatments like biological pacemaking.
Radiofrequency ablation of the sinoatrial node successfully establishes a long-term miniature swine model of sinus node dysfunction, providing a valuable tool for researching arrhythmia mechanisms and alternative treatments like biological pacemaking.
Ramírez et al. (2025) studied Sinus Node Dysfunction (n=9). Radiofrequency ablation of right atrial early activation sites was evaluated on Establishment of sinus node dysfunction (SND). Radiofrequency ablation of the sinoatrial node and right atrial early activation sites successfully established a long-term porcine model of sinus node dysfunction in 78% of subjects.
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