Key result
Epicardial ablation of the sinoatrial node resulted in the generation of chronic subsidiary atrial pacemaker activity in 60% of treated goats.
Why the study?
The function of the paranodal area remains debated, and large animal models of sinus node disease allow characterization of subsidiary atrial pacemakers as potential targets for novel treatments.
Population
10 goats
Comparison
Epicardial ablation of the SAN to assess emergent subsidiary atrial pacemakers
Design
Animal experimental study
Follow-up
4 weeks
Authors
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May guide biological pacemaker targets in sinus node disease; leaves open translation from this goat model.
In a goat model of sinus node disease, subsidiary atrial pacemakers develop in the paranodal area and exhibit specific electrophysiological and structural properties, suggesting a potential target for biological pacemakers.
Soattin et al. (2021) studied Sinus node disease (n=10). Epicardial ablation of the sinoatrial node was evaluated on Generation of chronic subsidiary atrial pacemaker (SAP) activity. Epicardial ablation of the sinoatrial node resulted in the generation of chronic subsidiary atrial pacemaker activity in 60% of treated goats.
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