Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 9, 2025Circulation Research

Abstract Thu165: X-linked Demethylase KDM6A is Differentially Required in Male and Female Hearts

View Full Paper
Ask AI
Bookmark
Share

Authors

LGLucia GrandisonUniversity of North Carolina at Chapel HillFCFrank L. ConlonUniversity of North Carolina at Chapel Hill

Discussion

Loading...

Member takes

Overview

Research reveals KDM6A's role in cardiac conduction and gene dysregulation, highlighting sex differences in hearts.

Key Points

  • KDM6A loss differentially affects cardiac conduction in adult male and female mice, indicating sex-specific functions.
  • Gene dysregulation in Kdm6a cmKO cardiomyocytes shows distinct pathways affected in males and females, including ion transport.
  • Utilizing a CM-specific KDM6A conditional null mouse model allows exploration of sex-based developmental differences in heart.
  • Understanding KDM6A's role could illuminate biological mechanisms of sex differences in heart health and disease.

Cite This Study

Grandison et al. (2025) studied this question.

synapsesocial.com/papers/68e80eb363e2e2f707877df5https://doi.org/10.1161/res.137.suppl_1.thu165
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 125: The X Chromosome Gene Kdm6a Confers Sex Differences In Mature Adipocyte Function Impacting Cardiometabolic Health2024 · 1 citations
  2. 2KDM6A facilitates Xist upregulation at the onset of X inactivation2024
  3. 3The Epigenetic Regulator Histone Demethylase KDM5A is Activated and Pathogenic in a Mouse Model of Heart Failure2026
  4. 4Deletion of the X-chromosomal gene Kdm6a in microglia of female mice ameliorates neuroinflammation and restores translatome profiles2025 · 4 citations
  5. 5Sex-specific KDM6A-HNF4A-CREBH network controls lipoprotein cholesterol metabolism and atherosclerosis via epigenetic reprograming of hepatocytes2026