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October 17, 2025Science Translational Medicine

Deletion of the X-chromosomal gene Kdm6a in microglia of female mice ameliorates neuroinflammation and restores translatome profiles

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Authors

YIYuichiro ItohUniversity of California, Los AngelesNINoriko ItohUniversity of California, Los AngelesSWSophia WendinUniversity of California, Los Angeles

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Implication

Gene Kdm6a deletion significantly ameliorates neuroinflammation in female mice with MS, indicating sex differences in disease.

Key Points

  • Deletion of kdm6a in microglia significantly reduced neuroinflammation in female mice with MS.
  • Kdm6a expression is higher in female microglia, reflecting sex differences in multiple sclerosis pathology.
  • Microglial-specific deletion of kdm6a showed minimal effects on EAE pathology in male mice.
  • Metformin treatment that blocks KDM6A's activity improved neuroinflammation in females but not males.

Cite This Study

Itoh et al. (2025) studied this question.

synapsesocial.com/papers/68f199d1de32064e504dd61ahttps://doi.org/10.1126/scitranslmed.adq3401
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