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October 9, 2025Circulation Research

Abstract Wed004: Growth Differentiation Factor 11 Regulates Cardiomyocyte Cycling After Myocardial Infarction

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Authors

AEAlexander J EichertCPCaitlin M. PavelecAYA. P. Young

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Overview

Transgenic mice showed reduced LVEF and increased scar after MI, indicating GDF11's impact on cardiomyocyte cycling.

Key Points

  • GDF11 knockout markedly reduced left ventricular ejection fraction, compromising heart function.
  • LVEF was significantly lower across all time points in GDF11 KO compared to controls, confirming its role in recovery.
  • Gene expression via RNA-seq revealed over 4000 genes differentially expressed in cycling versus non-cycling cardiomyocytes.
  • The findings suggest GDF11 secretion may inhibit cardiomyocyte cycling, with implications for myocardial recovery.

Cite This Study

Eichert et al. (2025) studied this question.

synapsesocial.com/papers/68e82b12e7fc21a300500150https://doi.org/10.1161/res.137.suppl_1.wed004
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