Key result
Ablation of endogenously cycling adult cardiomyocytes caused progressive worsening of left ventricular chamber size and function after ischemia-reperfusion myocardial infarction compared to controls.
Why the study?
Whether scarce endogenously cycling adult cardiomyocytes contribute to myocardial function after myocardial infarction had not been tested due to a lack of suitable transgenic reporters.
Population
Transgenic mice including αDKRC::DTA and αDKRC::RLTG models
Comparison
Ablation of endogenously cycling adult cardiomyocytes in αDKRC::DTA mice vs controls after I/R MI
Design
Preclinical animal study
Authors
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New reporter mouse enables direct testing of cycling cardiomyocyte function post-MI; leaves open their contribution to recovery.
Endogenously cycling adult cardiomyocytes, although scarce, actively contribute to preserving myocardial function after ischemic injury.
Bradley et al. (2020) studied Myocardial Infarction (Ischemia-Reperfusion Injury) (n=8). Ablation of endogenously cycling adult cardiomyocytes (αDKRC::DTA) vs. Controls was evaluated on Left ventricular chamber size and function. Ablation of endogenously cycling adult cardiomyocytes caused progressive worsening of left ventricular chamber size and function after ischemia-reperfusion myocardial infarction compared to controls.
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