Genetic Characteristics May do not Track the Circadian Preference of a Shiftwork Brazillian Population - What is the Better Indicator

Introduction: The Period 3 (Per3) gene is associated with individual differences in several sleep and circadian functions. Shift workers experience sleep restriction and exposure to wakefulness during an adverse circadian phase. Workers who carry genetic polymorphisms in the Per3 gene may experience particularly high levels of sleepiness during the night shift, which can lead to the development of various diseases. They may also be at greater risk for automotive or occupational accidents when assigned to work hours that do not align with their chronotype profile. We hypothesize that the Morningness and Eveningness Questionnaire, also known as the AutoMEQ, developed by Horne and Östberg in 1976 (HO), may not be sufficient for defining work schedules in companies. It would, therefore, be necessary to include the evaluation of Per3 gene polymorphism to make more accurate decisions.