Key result
Individuals homozygous for the PER3 5/5 allele displayed reduced global heart rate variability and elevated sympathetic predominance during baseline sleep compared to PER3 4/4 carriers.
Why the study?
Does the PER3 polymorphism affect cardiac autonomic control during sleep and wakefulness in healthy individuals?
Population
22 healthy participants selected according to their PER3 genotype (13 PER3 and 9 PER3 subjects), free from…
Comparison
PER3 genotype and 40-hour sleep deprivation… vs PER3(4/4) genotype and baseline sleep
Design
Cohort
Follow-up
4 days
Authors
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No immediate practice change in healthy adults; leaves open PER3 genotyping for autonomic risk in sleep disorders.
Observational (n=22)
No
Does the PER3 polymorphism affect cardiac autonomic control during sleep and wakefulness in healthy individuals?
Absolute Event Rate: 0.73% vs 0.65%
p-value: p=0.002
The PER3 polymorphism affects sympathovagal balance during NREM sleep, with the PER3(5/5) genotype showing increased sympathetic predominance similar to the effects of sleep deprivation.
Viola et al. (2008) conducted an observational in Healthy participants (n=22). PER3 5/5 genotype vs. PER3 4/4 genotype was evaluated on Sympathovagal balance (LF/(LF+HF) ratio) during baseline sleep (p=0.002). Individuals homozygous for the PER3 5/5 allele displayed reduced global heart rate variability and elevated sympathetic predominance during baseline sleep compared to PER3 4/4 carriers.
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