Silver-Catalyzed Synthesis of Polyfunctionalized 1,7- and 2,7- Benzonaphthyridine Scaffolds and their Access to Perlolidine Derivatives

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This is a Experimental Study study.

Kirti Vashishtha; Kapil Chahal; Namita Bhoi; Donamol Tomy; Balasubramanian Sridhar; Manjula Alla; K. Rajender Reddy

doi:10.1039/d5ob01410g

January 1, 2025Organic & Biomolecular Chemistry

Silver-Catalyzed Synthesis of Polyfunctionalized 1,7- and 2,7- Benzonaphthyridine Scaffolds and their Access to Perlolidine Derivatives

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Key Points

The synthesis achieved high yields and excellent selectivity in producing benzo[b][1,7] and benzo[c][2,7]-naphthyridines, demonstrating its effectiveness.
Sequential Michael addition followed by cyclization led to polyfunctionalized derivatives, showcasing the versatility of the method.
The one-pot synthesis simplifies the process while maintaining high chemoselectivity, marking a notable advancement in organic chemistry.
This approach could pave the way for developing novel perlolidine derivatives through subsequent transformations.

Implication

The silver-catalyzed approach yields high selectivity and efficiency in creating benzonaphthyridine scaffolds, suggesting significant utility in organic synthesis.

Abstract

A regio- and chemoselective silver-catalyzed one-pot synthesis of benzo[b][1,7]- and benzo[c][2,7]-naphthyridines has been developed via a sequential Michael addition and silver-mediated cyclization strategy. The protocol exhibits excellent selectivity, high yields,...

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Cite This Study

Vashishtha et al. (2025) studied this question.

synapsesocial.com/papers/68e861857ef2f04ca37e3a73 https://doi.org/10.1039/d5ob01410g

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Silver-Catalyzed Synthesis of Polyfunctionalized 1,7- and 2,7- Benzonaphthyridine Scaffolds and their Access to Perlolidine Derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

Silver-Catalyzed Synthesis of Polyfunctionalized 1,7- and 2,7- Benzonaphthyridine Scaffolds and their Access to Perlolidine Derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

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