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October 10, 2025American Journal of Medical Genetics Part B Neuropsychiatric GeneticsOpen Access

Molecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and Discovery of New Variants in Amazonian Amerindian Populations

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Authors

ASAline Pasquini SantosTSTatiane Carinta de SouzaKAKaio Evandro Cardoso Aguiar

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Overview

Analysis identifies unique genetic variants impacting methylphenidate response in ADHD patients, suggesting tailored treatments for indigenous individuals.

Key Points

  • Three novel genetic variants specific to indigenous populations may influence methylphenidate response in ADHD.
  • A statistically significant high-impact variant in the COMT gene was notable in the INDG population.
  • This study utilized whole-exome sequencing to profile genes associated with methylphenidate therapy in ADHD.
  • Findings support the potential of precision medicine to enhance therapeutic outcomes for ADHD in diverse genetic backgrounds.

Cite This Study

Santos et al. (2025) studied this question.

synapsesocial.com/papers/68e861907ef2f04ca37e3e44https://doi.org/10.1002/ajmg.b.33064
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pharmacogenomics of Major Depressive Disorder in Indigenous Amazonian Populations2026
  2. 2Pharmacogenetics and its impact on pharmacological management of severe attention deficit hyperactivity disorder2025
  3. 3Evaluation of dopamine transporter gene variations in Turkish children with attention deficit hyperactivity disorder treated with methylphenidate adverse effects2026
  4. 4Exploring the relationship between admixture and genetic susceptibility to attention deficit hyperactivity disorder in two Latin American cohorts2024 · 2 citations
  5. 5Cortical alterations associated with lower response to methylphenidate in adults with ADHD2024 · 9 citations