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January 18, 2026Clinical Pharmacology & TherapeuticsOpen Access

Pharmacogenomics of Major Depressive Disorder in Indigenous Amazonian Populations

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Authors

KAKaio Evandro Cardoso AguiarNSN. C. da SILVAJRJuliana Carla Gomes Rodrigues

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Overview

Genetic evaluation reveals unique variants associated with antidepressant response in Indigenous populations, suggesting tailored treatment protocols.

Key Points

  • The study aims to explore the genetic variants affecting antidepressant efficacy in Indigenous Amazonian populations.
  • Characterized the molecular profile of nine pharmacogenes using whole exome sequencing.
  • Analyzed 64 Indigenous individuals from the Amazon.
  • Compared allele frequencies of genetic variants with other world populations.
  • Utilized Fisher’s exact test for statistical analysis.
  • Identified 125 genetic variants, including 6 possible new variants unique to the population.
  • Detected 9 variants with significant frequency differences in the Indigenous population compared to global populations.
  • Confirmed the unique genetic profile of the Brazilian Amazon Indigenous population.

Cite This Study

Aguiar et al. (2026) studied this question.

synapsesocial.com/papers/696c789ceb60fb80d1396d42https://doi.org/10.1002/cpt.70207
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Also Consider

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  1. 1Investigation of Pharmacogenomic Variants in the CYP (P450) Family in Native American Populations of the Brazilian Amazon2026
  2. 2Pharmacogenomic diversity in Amazonian Indigenous populations: implications for Berlin–Frankfurt–Münster acute lymphoblastic leukemia therapy2026
  3. 3Genetic Variation in <scp>ADHD</scp> ‐Related Risk Genes in an Indigenous Population of the Amazon2026
  4. 4Molecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and Discovery of New Variants in Amazonian Amerindian Populations2025
  5. 5The influence of pharmacogenetics on the treatment-related outcomes of antidepressants and antipsychotics in Brazil: a systematic review2026