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August 13, 2026American Journal of Medical Genetics Part B Neuropsychiatric GeneticsOpen Access

Genetic Variation in ADHD ‐Related Risk Genes in an Indigenous Population of the Amazon

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Authors

HMHirlesson Paixão de MatosNMNatasha MonteKAKaio Evandro Cardoso Aguiar

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Overview

Randomized trial analyzes genetic variation in ADHD-related genes in Indigenous populations, highlighting unique profiles.

Key Points

  • This study investigates genetic variation in ADHD-related genes in Indigenous populations of the Amazon.
  • Analyzed exome data from 64 individuals across 12 Indigenous groups.
  • Compared genetic variation with reference populations from the 1000 Genomes Project.
  • Identified significant allele frequency differences for 56 variants.
  • Four previously unreported variants found in ADGRL3, DCC, and FOXP2.
  • 99 variants met the inclusion criteria for analysis.
  • Multidimensional scaling indicated significant genetic differentiation from other populations.

Cite This Study

Matos et al. (2026) studied this question.

synapsesocial.com/papers/6a7d76aa2b0e0cff3f6403efhttps://doi.org/10.1002/ajmg.b.70028
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