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July 26, 2026Pharmacogenomics

Evaluation of dopamine transporter gene variations in Turkish children with attention deficit hyperactivity disorder treated with methylphenidate adverse effects

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Authors

KPKübra Çiğdem Pekkoç-UyanıkMBMelik Yigit BayindirMAMuhammet Fatih Akdemir

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Overview

Randomized trial evaluates dopamine transporter gene variations and adverse effects in ADHD children, suggesting genetic influence.

Key Points

  • The study aims to evaluate how variations in the DAT1 gene affect the adverse effects of methylphenidate in children with ADHD.
  • Included 47 children diagnosed with ADHD receiving methylphenidate treatment.
  • Adverse effects assessed using Barkley Stimulants Side Effects Rating Scale.
  • Sequenced the DAT1 gene exons using next-generation sequencing (NGS).
  • Identified 16 variants in the DAT1 gene, including common and rare types.
  • Significant genetic associations found for rs1042098 (p = 0.003, BH q = 0.019) and rs6876890 (p = 0.008, BH q = 0.044) regarding adverse effects.

Cite This Study

Pekkoç-Uyanık et al. (2026) studied this question.

synapsesocial.com/papers/6a65a7b4d3aea3239cd78625https://doi.org/10.1080/14622416.2026.2706504
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Testing <i>DAT1</i> and <i>DRD4</i> Genes in Attention Deficit Hyperactivity Disorder Using a Wide Spectrum of Neurocognitive Batteries2026
  2. 2Gene-gene and gene-environmental interaction of dopaminergic system genes in Pakistani children with attention deficit hyperactivity disorder2024 · 5 citations
  3. 3Molecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and Discovery of New Variants in Amazonian Amerindian Populations2025
  4. 4Influence of genetic background on the clinical picture of bipolar affective disorder in a population of children and adolescents2024
  5. 5Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies2009