This research demonstrates the effectiveness of phosphine catalysis for asymmetric cyclization, suggesting a novel approach for oxetane-derived compounds.
We have successfully applied 3-oxetanone derived MBH carbonates in the phosphine catalyzed asymmetric [3+2] cyclization with activated thioaurones. With L-threonine derived amide phosphine as the catalyst, a series of oxetane bis-spiro cyclopentene skeletons, involving two spiral scaffold with vicinal tertiary and quaternary stereocenters, were constructed in good yield with good enantioselectivity and moderate to good distereoselectivity.Key words oxetane,
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Ding et al. (2025) studied this question.
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