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October 10, 2025ImmunologyOpen Access

LAG‐3+ Regulatory T Cells Suppress Effector Function of T Cells and Allow Their Proliferation Into Regulatory T Cells

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Regulatory T cells inhibit effector functions in CD4+ T cells, suggesting a pathway for immune tolerance.

Regulatory T cells suppress the effector function of cognate antigen-specific CD4+ T cells, enhancing tolerance.
In vitro, LAG-3+ T cells inhibit IFN-γ responses and show increased immune checkpoint expression, indicating functional modulation.
Adoptive transfer of LAG-3+ T cells rescues mice from lethal autoimmune pulmonitis in a dose-dependent manner.
Genomic studies show retained proliferative capacity in suppressed T cells, despite reduced oxidative metabolism.

Dutta et al. (2025) studied this question.

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October 10, 2025ImmunologyOpen Access

View Full Paper

Ask AI

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Authors

Regulatory T cells inhibit effector functions in CD4+ T cells, suggesting a pathway for immune tolerance.

Regulatory T cells suppress the effector function of cognate antigen-specific CD4+ T cells, enhancing tolerance.
In vitro, LAG-3+ T cells inhibit IFN-γ responses and show increased immune checkpoint expression, indicating functional modulation.
Adoptive transfer of LAG-3+ T cells rescues mice from lethal autoimmune pulmonitis in a dose-dependent manner.
Genomic studies show retained proliferative capacity in suppressed T cells, despite reduced oxidative metabolism.

Dutta et al. (2025) studied this question.

View Full Paper

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Bookmark