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October 10, 2025The FASEB JournalOpen Access

Transition From a High‐Sugar and Butter to a Standard Diet Leads to Cecal Dysbiosis, Disrupts Intestinal Homeostasis, and Favors Increased Ethanol Consumption and Preference

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Authors

RJRenato Elias Moreira JúniorUniversidade Federal de Minas GeraisMMMiguel MendesPreventive CardiologyMAMariana Siqueira AmorminoUniversidade Federal de Minas Gerais

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Implication

Animal study reveals persistent intestinal dysbiosis and increased ethanol preference after diet transition, suggesting health risks.

Key Points

  • Switching to a standard diet increases vulnerability to ethanol consumption, indicating lasting metabolic effects.
  • Measurement of body weight and cecal microbiota composition shows dysbiosis persists despite dietary changes.
  • The approach involved switching a high-sugar diet to a standard diet for a predetermined duration in a mouse model.
  • Findings support the need for strategies to restore intestinal health after obesity to reduce alcohol-seeking behavior.

Cite This Study

Júnior et al. (2025) studied this question.

synapsesocial.com/papers/68e8619c7ef2f04ca37e4203https://doi.org/10.1096/fj.202502123r
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Also Consider

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