What type of study is this?

This is a Animal Study study (also classified as: Experimental Study).

October 10, 2025Open Access

CSF1R+ macrophage and osteoclast depletion impairs neural crest proliferation and craniofacial morphogenesis

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Pharmacological inhibition of csf1r signaling disrupts neural crest proliferation and craniofacial development.

Depletion of csf1r+ macrophages and osteoclasts impaired craniofacial morphogenesis, affecting skull shape.
Prenatal exposure to PLX5622 reduced csf1r+ macrophages by about 50% and eliminated osteoclasts.
Changes in cytokine and chemokine signaling indicate that csf1r+ macrophages play critical roles in neural crest proliferation.
Observation of strain-specific differences highlights the complex interaction in craniofacial development success.

Ma et al. (2025) studied this question.

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October 10, 2025Open Access

View Full Paper

Ask AI

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Authors

Pharmacological inhibition of csf1r signaling disrupts neural crest proliferation and craniofacial development.

Depletion of csf1r+ macrophages and osteoclasts impaired craniofacial morphogenesis, affecting skull shape.
Prenatal exposure to PLX5622 reduced csf1r+ macrophages by about 50% and eliminated osteoclasts.
Changes in cytokine and chemokine signaling indicate that csf1r+ macrophages play critical roles in neural crest proliferation.
Observation of strain-specific differences highlights the complex interaction in craniofacial development success.

Ma et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark