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July 10, 2026Journal of Developmental BiologyOpen Access

CSF1R+ Macrophages and Osteoclasts Are Essential for Limb Bone Development During Embryogenesis

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Authors

FMFelix MaUniversity of British ColumbiaRZRu ZhouUniversity of British ColumbiaMRMatthew RosinUniversity of British Columbia

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Overview

Randomized trial examines CSF1R disruption effects on limb bone development in embryos, suggesting crucial roles for CSF1R+ cells.

Key Points

  • This research investigates the roles of CSF1R+ macrophages and osteoclasts in limb bone development during embryogenesis.
  • Utilized the CSF1R inhibitor PLX5622 on pregnant mice throughout gestation.
  • Assessed embryonic limb development from E11.5 to E15.5.
  • Analyzed limb bones at postnatal day 1 for morphological changes.
  • CSF1R+ cells were significantly depleted with PLX5622 exposure, resulting in a complete loss of embryonic osteoclasts.
  • Prenatal PLX5622 exposure led to a truncated phenotype in all limb bones assessed at postnatal day 1.
  • Strain-specific defects were noted, particularly in the heel of CD1 mice with absent talus and underdeveloped calcaneus bones.

Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/6a508f236eeac72a437a17d4https://doi.org/10.3390/jdb14030031
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Also Consider

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  1. 1CSF1R+ macrophage and osteoclast depletion impairs neural crest proliferation and craniofacial morphogenesis2025 · 1 citations
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  3. 3Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer2024 · 4 citations
  4. 4Expression and Role of Colony Stimulating Factor 1 Receptor During Odontogenesis2026
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