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October 11, 2025Microbiology SpectrumOpen Access

Integrated multi-omics identifies dysregulated lipid metabolism of paresis in dairy sheep during the early transition period

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Longitudinal analysis identifies lipid and amino acid metabolism changes in dairy sheep with paresis, suggesting targeted interventions.

Lipid and amino acid metabolism are dysregulated in paretic dairy sheep, highlighting potential early diagnostic biomarkers.
Metabolomic analysis revealed 37 differential metabolites, with acylcarnitines as promising early biomarkers for paresis.
Microbiota analysis indicated distinct microbial signatures, with specific genera enriched in paretic compared to healthy dairy sheep.
Integration of multi-omics data provides insights for nutritional strategies to prevent periparturient metabolic disorders.

Jiao et al. (2025) studied this question.

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