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October 11, 2025The Journal of Infectious Diseases

Prevalence of candidate vaccine targets and genomic features of pediatric invasive Streptococcus agalactiae in Japan

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Authors

MKMasashi KasaiSNSatoshi NakanoSKShota Koide

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Overview

Nationwide genomic surveillance reveals high vaccine coverage and multidrug-resistant lineages of GBS in children.

Key Points

  • The study shows a high vaccine coverage of 98.3% for hexavalent polysaccharide vaccine in Japan.
  • Among 237 isolates, serotype III was the most prevalent at 48.1%, with significant antimicrobial resistance noted.
  • Genomic surveillance methods included whole-genome sequencing and SNP-based analyses for detailed lineage characterization.
  • The findings highlight local transmission routes of multidrug-resistant clones, indicating the need for targeted prevention strategies.

Cite This Study

Kasai et al. (2025) studied this question.

synapsesocial.com/papers/68e9b1b5ba7d64b6fc13215chttps://doi.org/10.1093/infdis/jiaf491
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