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October 11, 2025Journal of Cellular Physiology

Bidirectional Regulatory Mechanisms of Disulfidptosis Govern Precision Targeting in Degenerative Bone Diseases and Osteosarcoma

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Authors

XZXiaoming ZhaoSWShaobo WuXSXiaochen Su

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Overview

Review explores disulfidptosis's role in degenerative conditions and bone tumors, suggesting immunometabolic interventions.

Key Points

  • Disulfidptosis significantly influences the development of osteosarcoma and degenerative bone diseases.
  • Key regulatory mechanisms involve the SLC7A11 molecule, which plays a crucial role in cystine metabolism.
  • The analysis presents potential precision strategies combining disulfidptosis-targeted interventions with immunotherapy.
  • Understanding disulfidptosis may lead to novel approaches in managing orthopedic diseases and related tumors.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68e9b1c1ba7d64b6fc13232bhttps://doi.org/10.1002/jcp.70100
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Disulfidptosis in tumor progression2025 · 21 citations
  2. 2The emerging role of disulfidptosis in metabolic synergistic death and cancer immunotherapy2026 · 2 citations
  3. 3Research advances of disulfidptosis in inflammatory diseases2026
  4. 4Disulfidptosis: A Metabolic Cell Death Mechanism with Therapeutic Potential in Cancer2026 · 3 citations
  5. 5Experimental Detection Methods and Clinical Translational Challenges of Disulfidptosis in Cancer2026