What type of study is this?

This is a Quantitative Study study.

October 11, 2025Genome ResearchOpen Access

Recovering gene regulatory networks in single-cell multiomics data with PRISM-GRN

View Full Paper

Ask AI

Bookmark

PRISM-GRN reconstructs gene regulatory networks with higher precision than seven baseline methods under sparse interaction conditions.
It effectively uses multiomics data including scRNA-seq and scATAC-seq to capture causality in gene regulation.
Evaluation across four benchmarking datasets displays PRISM-GRN's adaptability to unpaired omics data and limited prior information.
Biological analyses of PBMC datasets showcase the model's potential for identifying context-specific GRNs in real-world applications.

No takes yet. Share an insight, caveat, or question.

Proposed PRISM-GRN demonstrates improved GRN reconstruction in multiomics data, highlighting flexibility and causality.

Zhang et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark