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This work aims to develop a comprehensive platform for analyzing gene regulatory networks across various cell types in humans and mice.

October 27, 2023Nucleic Acids ResearchOpen Access

scGRN: a comprehensive single-cell gene regulatory network platform of human and mouse

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This work aims to develop a comprehensive platform for analyzing gene regulatory networks across various cell types in humans and mice.
Development of scGRN platform utilizing single-cell transcriptomic and epigenomic data.
Cataloging of 237,051 cell type-specific GRNs across 160 tissues/cell lines and 1324 samples.
Implementation of online tools for differential TF-target network, TF enrichment, and pathway analysis.
The platform includes 62,999,692 TF-target gene pairs, providing extensive GRN information.
Insight into regulatory mechanisms across diverse conditions is enabled via interactive analysis tools.
Identification of TF binding to promoters and enhancers is documented in the database.

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Randomized trial demonstrates gene regulatory network insights in human and mouse, indicating potential for novel therapies.

Huang et al. (2023) studied this question.

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