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October 11, 2025BMC Medical GenomicsOpen Access

Molecular mechanisms underlying the co-pathogenesis of abdominal aortic aneurysm and rheumatoid arthritis: evidence based on bioinformatics analysis and clinical data

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Authors

YWYoufu WangLZLing ZhangWJWenhong Jiang

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Overview

Bioinformatics analysis reveals the role of ITK and immune cell types in AAA and RA pathogenesis.

Key Points

  • Elevated monocytes in patients with AAA and RA correlate with increased ITK expression.
  • Analysis identified 61 common differentially expressed genes between AAA and RA datasets.
  • Hub genes, particularly ITK, demonstrate significant involvement in the co-pathogenesis of AAA and RA.
  • Bioinformatics methods provided insights into the regulatory network linking ITK with related diseases.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68ea72339f1bd4df558cecb0https://doi.org/10.1186/s12920-025-02236-y
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