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October 11, 2025European journal of medical researchOpen Access

The miR-3164/PAD4 axis regulates NETosis to prevent airway inflammation and remodeling through the TLR2/NF-κB signaling pathway

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Authors

LHLiang HeRQRong QiangWLWeiqun Li

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Overview

This study demonstrates miR-3164 reduces airway inflammation and remodeling in asthma via NETosis and the TLR2/NF-κB signaling pathway.

Key Points

  • miR-3164 significantly suppressed PAD4 expression and modified NET formation in neutrophils.
  • Treatment with miR-3164 mimics downregulated inflammation-related biomarkers, improving airway smooth muscle cell conditions.
  • The dual-luciferase reporter assay confirmed the targeting relationship between miR-3164 and PAD4.
  • Modulating NETosis through miR-3164 offers a potential therapeutic intervention for asthma.

Cite This Study

He et al. (2025) studied this question.

synapsesocial.com/papers/68ea72339f1bd4df558cecc9https://doi.org/10.1186/s40001-025-03175-1
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