What type of study is this?

This is a Experimental Study study.

October 12, 2025The Journal of Organic Chemistry

Transition-Metal-Free Synthesis of Indolo[2,1-a]isoquinolines via Intramolecular Tandem Radical Cyclization

View Full Paper

Ask AI

Bookmark

Indolo[2,1-a]isoquinolines were rapidly synthesized through a new method that avoids metal catalysts.
Initial studies indicate a single electron transfer (SET) radical mechanism may be involved in the cyclization process.
The approach emphasizes regioselectivity in the tandem process, leading to diverse functionalized products.
This method could simplify synthetic pathways in organic chemistry and expand the repertoire of available compounds.

Implication

This research shows the construction of indolo[2,1-a]isoquinolines via metal-free tandem cyclization, suggesting a potential radical mechanism.

Abstract

Diversely functionalized indolo[2,1-a]isoquinolines were rapidly constructed by regioselective metal-free intramolecular tandem cyclization. Initial mechanistic studies revealed that a single electron transfer (SET) radical process was possibly involved.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Feng et al. (2025) studied this question.

synapsesocial.com/papers/68ebc91af2c3e4d8d926e18e https://doi.org/10.1021/acs.joc.5c02099

View Full Paper

Ask AI

Bookmark

Implication

This research shows the construction of indolo[2,1-a]isoquinolines via metal-free tandem cyclization, suggesting a potential radical mechanism.

Transition-Metal-Free Synthesis of Indolo[2,1-a]isoquinolines via Intramolecular Tandem Radical Cyclization

Key Points

Implication

Abstract

Discussion

Cite This Study

Transition-Metal-Free Synthesis of Indolo[2,1-a]isoquinolines via Intramolecular Tandem Radical Cyclization

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading