This research describes a method to synthesize indolo[3,2-c]quinolines from nitrophenylindoles and amines, highlighting its efficiency.
A S 8 ‐mediated hydrogen‐borrowing reduction/cyclization/aromatization strategy for the preparation of indolo[3,2‐ c ]quinolines has been described. The present procedure starts from 2‐(2‐nitrophenyl)indoles and amines, providing a wide range of indolo[3,2‐c]quinolines in 39%–75% yields under metal‐free conditions. In this work, nitro‐group reduction, CN bond cleavage, CN bond formation, and cyclization are achieved in one pot.
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Tan et al. (2026) studied this question.
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