Histoplasmosis disseminated in a worker: report of four cases

Introduction: Disseminated Histoplasmosis (DH) is a clinical subtype of Histoplasmosis, a disease with a worldwide distribution and strong presence in the Americas region. Objective: Describe four cases of HD in workers. Method: A retrospective and descriptive case series study was conducted on patients attended at a specialized teaching hospital for infectious diseases located in the Northeast region of Brazil. Results: Four cases of histoplasmosis, their clinical, laboratory manifestations, and evolution were analyzed. All the situations described were related to the DH subtype, a pathology with reserved prognosis and whose accurate diagnosis is still challenging. The four cases involved patients with AIDS. Conclusions: Coinfection between AIDS (HIV) and Histoplasma capsulatum was present in 100% of the sample; one of the cases was a triple coinfection between Histoplasma capsulatum, AIDS, and SARS-CoV-2. DH was a potentially fatal entity, with a progression to death in 100% of the described situations.