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October 12, 2025Open Access

TET CpG sequence context specific DNA demeth-ylation shapes progression of IDH-mutant gliomas

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Authors

YHYouri HoogstrateSGSantoesha A. GhisaiLHLevi van Hijfte

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Overview

Observational analysis shows tumor progression in IDH-mutant gliomas impacts DNA methylation, suggesting new prognostic grading methods.

Key Points

  • Increased DNA demethylation correlates with tumor progression in IDH-mutant gliomas, highlighting its role in tumor biology.
  • The newly developed continuous grading coefficient captures changes in DNA methylation more accurately than WHO grading.
  • Analysis of 302 primary and recurrent oligodendrogliomas revealed a continuum of DNA methylation changes linked to aggressiveness.
  • Findings indicate that IDH-mutant gliomas share an epigenetic axis with astrocytomas, indicating broader implications for treatment.

Cite This Study

Hoogstrate et al. (2025) studied this question.

synapsesocial.com/papers/68ebffcfdef9fcb308ff233ehttps://doi.org/10.1101/2025.10.09.681314
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1TET CpG sequence-context-specific DNA demethylation shapes progression of IDH-mutant gliomas2026 · 2 citations
  2. 2DNA methylation analysis reveals an epigenetic signature distinctive of high-grade oligodendroglioma2025
  3. 3AB019. Detailed analysis of DNA hydroxymethylation observed with the malignant progression of IDH-mutant gliomas2024
  4. 4Epigenetic landscape reorganization and reactivation of embryonic development genes are associated with malignancy in IDH-mutant astrocytoma2024 · 1 citations
  5. 5DNA methylation in glioblastoma: insights from single-cell epigenomics2026