Analysis reveals that high fat diet differentially impacts cognition and pathology in male and female Alzheimer’s mice, suggesting metabolic syndrome plays a distinct role.
Key Points
AD females showed greater cognitive and metabolic disturbances on a high fat diet than males.
HFD led to increased anxiety and impaired memory in both sexes, particularly in females with Alzheimer's disease.
Microglial activation and amyloid pathology in the thalamus were exacerbated in HFD-fed female AD mice.
Findings suggest that sex differences in response to metabolic conditions may alter Alzheimer's disease progression.