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October 12, 2025Frontiers in Bioscience-ScholarOpen Access

Molecular Basis of Oxidative Stress-Induced Acute Kidney Injury, Kidney Fibrosis, Chronic Kidney Disease, and Clinical Significance of Targeting Reactive Oxygen Species-Regulated Pathways to Treat Kidney Disease

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Authors

RKRamji KandelPRPriti RoyKSKamaleshwar P. Singh

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Overview

Review highlights the role of oxidative stress in kidney damage, suggesting targeted therapies may improve chronic kidney disease outcomes.

Key Points

  • Targeting oxidative stress may improve outcomes in chronic kidney disease, especially post-acute kidney injury.
  • Oxidative stress is implicated in the transition from acute kidney injury to chronic kidney disease, affecting key signaling pathways.
  • Understanding the molecular mechanisms involved in kidney fibrosis is crucial for developing effective treatments for renal diseases.
  • Current therapies are ineffective for managing kidney fibrosis, highlighting the need for new strategies focusing on oxidative stress.

Cite This Study

Kandel et al. (2025) studied this question.

synapsesocial.com/papers/68ec1be02b8fa9b2b78ad32bhttps://doi.org/10.31083/fbs38963
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Mechanisms and Treatment Approaches of Oxidative Stress andInflammation in the Development of Chronic Kidney Disease2026
  2. 2Transcriptomics reveal dysregulated genes during folic acid-induced acute injury and fibrosis in kidney and their attenuation by antioxidant N-acetyl cysteine2026
  3. 3Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease: From Molecular Mechanisms to Biomarkers and Targeted Therapies2026
  4. 4From Acute to Chronic: Unraveling the Pathophysiological Mechanisms of the Progression from Acute Kidney Injury to Acute Kidney Disease to Chronic Kidney Disease2024 · 76 citations
  5. 5Role of Uremic Toxins, Oxidative Stress, and Renal Fibrosis in Chronic Kidney Disease2024 · 29 citations