What question did this study set out to answer?

This study aims to identify target molecules affected by oxidative stress and evaluate the protective effects of N-acetyl cysteine on kidney injury and fibrosis.

June 10, 2026AJP Cell Physiology

Transcriptomics reveal dysregulated genes during folic acid-induced acute injury and fibrosis in kidney and their attenuation by antioxidant N-acetyl cysteine

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Authors

RKRamji KandelTexas Tech University PRPriti RoyTexas Tech University IWIrfan WarraichTexas Tech University

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Implication

Randomized trial identifies target genes altered by oxidative stress in kidney injury, suggesting protection by antioxidant treatment.

Key Points

This study aims to identify target molecules affected by oxidative stress and evaluate the protective effects of N-acetyl cysteine on kidney injury and fibrosis.
Utilized both in vitro cell culture and in vivo mice models to assess kidney injury and fibrosis.
Applied multiple analytical approaches including serum creatinine-albumin levels and RNA-sequencing.
Evaluated expression of fibrogenic marker genes related to cellular remodeling and signaling pathways.
Antioxidant N-acetyl cysteine effectively abrogated oxidative stress-induced cellular remodeling and activated profibrogenic genes.
Identified several target genes and signaling molecules linked to kidney function and extracellular matrix regulation in the context of acute kidney injury.
Highlighted the role of dysregulated genes in the pathophysiology of nephrotoxicant-induced kidney fibrosis.

Cite This Study

Kandel et al. (2026) studied this question.

synapsesocial.com/papers/6a28fef66f82f25be989c1a4 https://doi.org/10.1152/ajpcell.00746.2025

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Transcriptomics reveal dysregulated genes during folic acid-induced acute injury and fibrosis in kidney and their attenuation by antioxidant N-acetyl cysteine

Discussion

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Implication

Key Points

Cite This Study

Transcriptomics reveal dysregulated genes during folic acid-induced acute injury and fibrosis in kidney and their attenuation by antioxidant N-acetyl cysteine

Discussion

Member takes

Implication

Key Points

Cite This Study

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