Breast Lesions Evaluation With Dynamic Contrastenhanced Mri: A Histopathological Correlation Study

Introduction: Breast cancer is the most common cancer in Indian women, accounting for 25–31% of cases in urban areas. Mammography and ultrasonography are traditional tools for breast lesion evaluation, but mammography 1 sensitivity falls to 48% in dense breasts. Its limitations-such as incomplete axillary assessment and underestimation of disease-are overcome by MRI. DCE-MRI offers high sensitivity for detecting malignant lesions and helps distinguish scar from tumour after breast-conserving therapy. 2,3 As per American and European guidelines, breast MRI is the most sensitive modality for breast cancer detection. To evaluate the Aim/Purpose: role of dynamic contrast-enhanced MRI in detecting breast lesions and correlating with histopathology. This Material And Methods: prospective analytical study was conducted at GIMSR Hospital in patients aged 18–90 years who underwent contrast-enhanced MRI on a 1.5T Philips scanner for lesions evaluation or screening, with subsequent histopathological correlation. Results: Kinetic curves significantly correlated with histopathology: Type I (benign 35.3%), Type II (benign 52.9%, malignant 11.4%), Type III (malignant 88.6%) (p<0.001). BIRADS also showed strong association: benign mainly I–III, malignant predominantly IV (34.1%) and V (65.9%) (p<0.001). Conclusion: Dynamic contrast analysis showed that rapid initial enhancement and washout patterns were highly predictive of malignancy (p<0.001). Type III curves had the strongest correlation. Using BI-RADS IV as the malignancy cut-off, MRI demonstrated 100% sensitivity and 76.4% specificity, with PPV of 91.6% and NPV of 100%.